ジャーナルクラブ
| Date | Presented by | Article |
| 2026.1.29 | Hidenori Torio | Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis Yuki Masuo,et al. Sci Immunol.15;10(110):eadt3955,2025 |
| 2026.1.22 | Reona Tanimura | Gut microbiota promotes immune tolerance at the maternal-fetal interface Julia A Brown,et al. Cell.189(1):196-214.e24,2026 |
| 2026.1.15 | Ryota Sato | CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model Danni Y. Zhu,et al. Sci Immunol.10(113)eads8226,2025 |
| 2025.12.18 | Nana Uematsu | Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus Qintao Wang,et al. Nature.647:498–505,2025 |
| 2025.11.6 | Ayako Kitada | Enrichment of decidual CD11c + CD8 + T cells with altered immune function in early pregnancy loss. Ling Guo,et al. Nat Commun.16(1):6678,2025 |
| 2025.10.30 | Saori Abe | Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. Alice Horisberger,et al. J Clin Invest.135(16),2025 |
| 2025.10.2 | Yuka Yoshiki | Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract. Alexander J Nelson,et al. Immunity.58(4):875-888,2025 |
| 2025.9.25 | Hidenori Torio | Neutrophil single-cell analysis identifies a type II interferon-related subset for predicting relapse of autoimmune small vessel vasculitis. Masayuki Nishide,et al. Nat Commun.16(1):3581,2025 |
| 2025.7.10 | Satoshi Akao | Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice. Huiying Wang,et al. Nat Commun.16(1):4686,2025 |
| 2025.7.3 | Hiromitsu Asashima | Granzyme K activates the entire complement cascade. Carlos A Donado,et al. Nature.641(8061):211-221,2025 |
| 2025.6.19 | Ryohei Nishino | Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity. Keisuke Imabayashi,et al. Sci Adv.11(16):eadt8199,2025 |
| 2025.6.12 | Taihei Nisiyama | An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence. Asma Farhat,et al. Sci Immunol.10(105):eadk5041,2025 |
| 2025.6.5 | Ayako Kitada | Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome. Silvia Giugliano,et al. Nat Commun.16(1):4326,2025 |
| 2025.5.22 | Airi Kondo | Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease. Jae-Won Yoon,et al. Nat Commun.16(1):1962,2025 |
| 2025.5.15 | Reona Tanimura | PD-1 activation mitigates lupus nephritis by suppressing hyperactive and heterogeneous PD-1+CD8+ T cells. Jun Deng,et al. Theranostics.15(11):5029-5044,2025 |
| 2025.5.8 | Shusuke Tanaka | Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity. Klein B, et al. Sci Immunol.10(105):eado1710,2025 |
| 2025.3.13 | Taihei Nishiyama | Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. Xin Chen,et al. Nat Immunol.26(2):230-239,2025 |
| 2025.3.6 | Ayako Kitada | Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Weirong Chen,et al. Nat Commun.15(1):1899,2024 |
| 2025.2.20 | Ryota Sato | An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling. Laura Lau,et al. Nat Commun.16(1):968,2025 |
| 2025.2.13 | Ayako Ohyama | Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis. Yong Duz,et al. J Exp Med.222(3):e20231809,2025 |
| 2025.2.6 | Haruka Miki | Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring. Tomoaki Takao,et al. Nat Commun.16(1):631,2025 |
| 2025.1.30 | Hiromitsu Asashima | Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Masato Ogishi,et al. Immunity.57(12):2790-2807,2024 |
| 2025.1.23 | Satoshi Akao | Type I IFN drives unconventional IL-1β secretion in lupus monocytes. Simone Caielli,et al. Immunity.57(11):2497-2513,2024 |
| 2024.12.19 | Saori Abe | Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE. Caterina E Faliti,et al. Nat Immunol.26(1):131-145,2025 |
| 2024.12.12 | Ryohei Nishino | CD38 in SLE CD4 T cells promotes Ca2+ flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane. Eri Katsuyama,et al. Nat Commun.15(1):8304,2024 |
| 2024.11.28 | Airi Kondo | TGF-β-mediated crosstalk between TIGIT+ Tregs and CD226+CD8+ T cells in the progression and remission of type 1 diabetes. Ting Zhong,et al. Nat Commun.15(1):8894,2024 |
| 2024.11.21 | Reona Tanimura | Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion. Sophie Hillion,et al. Nat Commun.15(1):7982,2024 |
| 2024.11.14 | Syusuke Tanaka | Autoregulated splicing of TRA2 β programs T cell fate in response to antigen-receptor stimulation. Timofey A Karginov,et al. Science.385(6714):eadj1979,2024 |
| 2024.11.7 | Taihei Nishiyama | Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation. Darren R Heintzman,et al. Sci Immunol.9(99):eadp3475,2024 |
| 2024.10.31 | Ayako Kitada | Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome. Chenyang Lu,et al. Ann Rheum Dis.83(5):624-637,2024 |
| 2024.10.24 | Ryota Sato | Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner. Mohamed Reda Fazazi,et al. Nat Commun.15(1):5404,2024 |
| 2024.10.17 | Ayako Ohyama | Recognition and control of neutrophil extracellular trap formation by MICL. Mariano Malamud,et al. Nature.633(8029):442-450,2024 |
| 2024.10.3 | Yuya Kondo | Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling. Takahiro Nakajima,et al. Cell Mol Immunol,21(11):1266-1281,2024 |
| 2024.9.26 | Haruka Miki | Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis. Tatsuya Tsukui,et al. Nature.631(8021):627-634,2024 |
| 2024.9.19 | Hiromitsu Asashima | Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc) Minrui Liang,et al. Ann Rheum Dis.83(9):1144-1155,2024 |
| 2024.9.12 | Satoshi Akao | IL-12 drives the differentiation of human T follicular regulatory cells. Diana Castaño,et al. Sci Immunol.9(97):eadf2047,2024 |
| 2024.9.5 | Saori Abe | Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus. Calvin Law,et al. Nature.631(8022):857-866,2024 |
| 2024.7.25 | Ryohei Nishino | CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses. Marc Scherlinger,et al. Nat Commun.15(1):840,2024 |
| 2024.7.18 | Airi Kondo | EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3.Gan Wu,et al. Ann Rheum Dis.83(5):564-575,2024 |
| 2024.7.11 | Ryota Sato | Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. Xin Li,et al. Immunity.57(7):1603-1617,2024 |
| 2024.7.4 | Reona Tanimura | Smith-specific regulatory T cells halt the progression of lupus nephritis. Peter J Eggenhuizen,et al. Nat Commun.15(1):899,2024 |
| 2024.6.27 |
Syusuke Tanaka |
PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus. John Tchen,et al. Nat Commun.15(1):3389,2024 |
| 2024.6.20 |
Ayako Ohyama |
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. Hui Wang,et al. Cell,2024(Online ahead of print.) |
| 2024.6.13 | Haruka Miki | A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice. Gang Jin,et al. Nat Immunol.25(6):1059-1072,2024 |
| 2024.5.29 | Hiromitsu Asashima |