ジャーナルクラブ
| Date | Presented by | Article |
| 2023.5.11 | Taihei Nishiyama | Human T follicular helper clones seed the germinal center-resident regulatory pool. Carole Le Cozet al. Sci Immunol. 8(82):eade8162,2023 |
| 2023.3.16 | Hirofumi Toko | Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis. Lomon So,et al. J Exp Med.220(3):e20221676,2023 |
| 2023.3.9 | Ryota Sato | Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. Kelsey Voss,et al. Sci Immunol.8(79):eabq0178,2023 |
| 2023.3.2 | Ayako Kitada | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. Xue Chen,et al. Nat Commun.13(1):2762,2022 |
| 2023.2.9 | Ayako Ohyama | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis. Jae-Seung Moon,et al. Nat Commun.14(1):319,2023 |
| 2023.2.2 | Haruka Miki | Allergenic food protein consumption is associated with systemic IgG antibody responses in non-allergic individuals. Sigal Leviatan,et al. Immunity.55(12):2454-2469,2022 |
| 2023.1.26 | Reona Tanimura | IL-17-producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice. Vera Kim,et al. JCI Insight. 7(11):e157332,2022 |
| 2023.1.19 | Hiromitsu Asashima | Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis. Ian D Odell,et al. Sci Immunol. 7(78):eabq6691,2022 |
| 2023.1.12 | Taihei Nishiyama | Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses. Huimin Zhang,et al. Nat Immunol. 24(1):96-109,2023 |
| 2022.12.22 | Hirofumi Toko | Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus. Chuang Guo,et al. Cell Rep. 41(6):111606,2022 |
| 2022.12.15 | Yuya Kondo | Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes. Marco A Ataide,et al. Immunity.55(10):1813-1828,2022 |
| 2022.12.1 | Tamaki Iwai | ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Minglu Yan,et al. Nat Immunol. 23(9):1330-1341,2022 |
| 2022.11.24 | Ryota Sato | Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells. Rui Yang,et al. Sci Immunol. 22;7(73):eabq3277,2022 |
| 2022.11.17 | Ayako Ohyama | Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications. Yan Ye,et al. Nat Commun. 13(1):6458,2022 |
| 2022.11.10 | Haruka Miki | Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion. Tomohisa Iinuma,et al. J Allergy Clin Immunol.150(4):850-860,2022 |
| 2022.10.27 | Ayako Kitada | Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus. Richard K Perez,et al. Science.376(6589):eabf1970,2022 |
| 2022.10.20 | Reona Tanimura | Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus. Claire Leibler,et al. Nat Immunol.23(10):1457-1469,2022 |
| 2022.9.29 | Taihei Nishiyama | Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation. Alan Kennedy,et al. Nat Immunol. 23(9):1365-1378,2022 |
| 2022.9.22 | Hirofumi Toko | Single cell sequencing identifies clonally expanded synovial CD4 + T PH cells expressing GPR56 in rheumatoid arthritis. Alexandra Argyriou,et al. Nat Commun.13(1):4046,2022 |
| 2022.9.15 | Tamaki Iwai | Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis. Yuye Yin,et al. Nat Immunol.23(9):1342-1354,2022 |
| 2022.9.8 | Hiromitsu Asashima | Granzyme K + CD8 T cells form a core population in inflamed human tissue. A Helena Jonsson,et al. Sci Transl Med. 14(649):eabo0686,2022 |
| 2022.7.28 | Ryota Sato | Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity. Zhenhuan Zhao,et al. Ann Rheum Dis. 81(7):1006-1012,2022 |
| 2022.7.21 | Ayako Ohyama | Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Changlu Xu,et al. Nat Immunol. 23(7):1109-1120,2022 |
| 2022.7.14 | Reona Tanimura | Loss of CD11b Accelerates Lupus Nephritis in Lyn-Deficient Mice Without Disrupting Glomerular Leukocyte Trafficking. Timothy A Gottschalk, et al. Front Immunol.13:875359,2022 |
| 2022.7.7 | Haruka Miki | Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases. Ilya Korsunsky, et al. Med. 3(7):481-518,2022 |
| 2022.6.30 | Ayako Kitada | Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function. Sabrina Meisgen et al. Ann Rheum Dis.81(8):1151-1161,2022 |
| 2022.6.9 | Taihei Nishiyama | Cytoplasmic DNA sensing by KU complex in aged CD4 + T cell potentiates T cell activation and aging-related autoimmune inflammation. Yan Wang, et al. Immunity.54(4):632-647,2021 |
| 2022.6.2 | Hirofumi Toko | KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Jing Li, et al. Science.376(6590):eabi9591,2022 |
| 2022.5.26 | Tamaki Iwai | Natural Killer Cells Infiltration in the Joints Exacerbates Collagen-Induced Arthritis. Lisheng Wu, et al. Front Immunol. 13:860761,2022 |
| 2022.5.12 | Reona Tanimura | TLR7 gain-of-function genetic variation causes human lupus. Grant J Brown, et al. Nature. 605(7909):349-356,2022 |
| 2022.3.10 | Tamaki Iwai | PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Daisuke Sugiura, et al. Nat Immunol. 23(3):399-410,2022 |
| 2022.3.3 |
Taihei Nishiyama | Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice. Cecilia B Cavazzoni, et al. Cell Rep. 38(8):110399,2022 |
| 2022.2.17 | Hirofumi Toko | The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses. Samantha A Chalmers, et al. J Clin Invest. 132(1):e147334,2022 |
| 2022.2.10 | Fumika Honda | Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Bowen Wu, et al. Nat Immunol. 22(12):1551-1562,2021 |
| 2022.2.3 | Yuya Kondo | Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Wenzhi Song, et al. Immunity. 55(2):290-30,2022 |