ジャーナルクラブ
| Date | Presented by | Article |
| 2024.7.11 | Ryota Sato | Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. Xin Li,et al. Immunity.57(7):1603-1617,2024 |
| 2024.7.4 | Reona Tanimura | Smith-specific regulatory T cells halt the progression of lupus nephritis. Peter J Eggenhuizen,et al. Nat Commun.15(1):899,2024 |
| 2024.6.27 |
Syusuke Tanaka |
PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus. John Tchen,et al. Nat Commun.15(1):3389,2024 |
| 2024.6.20 |
Ayako Ohyama |
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. Hui Wang,et al. Cell,2024(Online ahead of print.) |
| 2024.6.13 | Haruka Miki | A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice. Gang Jin,et al. Nat Immunol.25(6):1059-1072,2024 |
| 2024.5.29 | Hiromitsu Asashima | Vagus nerve stimulation modulates distinct acetylcholine receptors on B cells and limits the germinal center response. Izumi Kurata-Sato,et al. Sci Adv.10(17):eadn3760,2024 |
| 2024.5.23 | Satoshi Akao | Disrupted degradative sorting of TLR7 is associated with human lupus. Harshita Mishra,et al. Sci Immunol.9(92):eadi9575,2024 |
| 2024.5.16 | Saori Abe | TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Mohammad H Dezfulian,et al. Cell.186(25):5569-5586,2023 |
| 2024.5.9 | Taihei Nishiyama | Age-associated CD4+ T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity. Manaka Goto,et al. Sci Immunol.9(93):eadk1643,2024 |
| 2024.5.2 | Ayako Kitada | Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Weirong Chen,et al. Nat Commun.15(1):1899,2024 |
| 2024.3.14 | Hirofumi Toko | The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates. Xin Zhao,et al. Nat Immunol.25(2):294-306,2024 |
| 2024.2.29 | Ryota Sato | The transcription factor ZEB2 drives the formation of age-associated B cells. Dai Dai,et al. Science.383(6681):413-421,2024 |
| 2024.2.22 | Ayako Ohyama | Xist ribonucleoproteins promote female sex-biased autoimmunity. Diana R Dou,et al. Cell.187(3):733-749,2024 |
| 2024.2.15 | Haruka Miki | Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis. Natsuko Otaki,et al. Nat Commun.14(1):8120,2023 |
| 2024.2.8 | Reona Tanimura | Amelioration of Autoimmunity in a Lupus Mouse Model by Modulation of T-Bet-Promoted Energy Metabolism in Pathogenic Age/Autoimmune-Associated B Cells. Arthritis Rheumatol. 75(7):1203-1215,2023 |
| 2024.2.1 | Hiromitsu Asashima | Bona fide dendritic cells are pivotal precursors for osteoclasts. Antonia Puchner,et al. Ann Rheum Dis,2023(Online ahead of print.) |
| 2024.1.25 | Yuya Kondo | Sensory neurons promote immune homeostasis in the lung. Masato Tamari,et al. Cell.187(1):44-61,2024 |
| 2023.12.21 | Satoshi Akao | Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis. Satoshi Nakamizo,et al. J Clin Invest.133(23):e171088,2023 |
| 2023.12.14 | Saori Abe | Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency. Tom Le Voyer,et al. Nature.623(7988):803-813,2023 |
| 2023.12.7 | Taihei Nishiyama | Resident regulatory T cells reflect the immune history of individual lymph nodes. Anne Kaminski,et al. Sci Immunol.8(89):eadj5789,2023 |
| 2023.11.16 | Hirofumi Toko | Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis. Jae-Seung Moon,et al. Nat Commun.14(1):5382,2023 |
| 2023.11.9 | Ayako Kitada | Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation. Xia Chen,et al. Immunity.56(2):336-352,2023 |
| 2023.11.2 | Ryota Sato | Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses. Nicole M Arroyo-Díaz,et al. Immunity.56(10):2358-2372,2023 |
| 2023.10.26 | Ayako Ohyama | The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance. Matthew K McElwee,et al. J Exp Med.220(12):e20230209,2023 |
| 2023.10.19 | Haruka Miki | Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Kami Pekayvaz,et al. Immunity.56(10):2325-2341,2023 |
| 2023.10.12 | Reona Tanimura | Ezh2 Knockout in B Cells Impairs Plasmablast Differentiation and Ameliorates Lupus-like Disease in MRL/lpr Mice. Xiaoqing Zheng,et al. Arthritis Rheumatol.75(8):1395-1406,2023 |
| 2023.9.28 | Hiromitsu Asashima | Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells. Antoine Freuchet,et al. Nat Immunol.24(10):1748-1761,2023 |
| 2023.9.21 | Saori Abe | Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate. Fangming Zhu, et al. Nat Commun.14(1):3611,2023 |
| 2023.7.27 | Taihei Nishiyama | PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance. Mandy van Gulijk,et al. Sci Immunol.8(83):eabn6173,2023 |
| 2023.7.20 | Ryota Sato | Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. Carlos E Rivera,et al. Sci Adv.9(17):eade8928,2023 |
| 2023.7.13 | Hirofumi Toko | How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion. Xuguang Tai,et al. Nat Immunol. 24(4):637-651,2023 |
| 2023.7.6 | Ayako Kitada | Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Melanie H Smith,et al Nat Immunol.24(7):1200-1210,2023 |
| 2023.6.29 | Ayako Ohyama | Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization. Ying-Han Chen,et al. Sci Immunol.8(84):eadd6910,2023 |
| 2023.6.15 | Haruka Miki | A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma. Jehan Alladina,et al. Sci Immunol. 8(83):eabq6352,2023 |
| 2023.6.8 | Reona Tanimura | Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells. Louise Malle,et al. Nature.615(7951):305-314,2023 |
| 2023.6.1 | Hiromitsu Asashima | Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis. Melissa G Lechner,et al. Sci Transl Med.15(696):eadg0675,2023 |
| 2023.5.11 | Taihei Nishiyama | Human T follicular helper clones seed the germinal center-resident regulatory pool. Carole Le Coz,et al. Sci Immunol. 8(82):eade8162,2023 |
| 2023.3.16 | Hirofumi Toko | Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis. Lomon So,et al. J Exp Med.220(3):e20221676,2023 |
| 2023.3.9 | Ryota Sato | Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. Kelsey Voss,et al. Sci Immunol.8(79):eabq0178,2023 |
| 2023.3.2 | Ayako Kitada | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. Xue Chen,et al. Nat Commun.13(1):2762,2022 |
| 2023.2.9 | Ayako Ohyama | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis. Jae-Seung Moon,et al. Nat Commun.14(1):319,2023 |
| 2023.2.2 | Haruka Miki | Allergenic food protein consumption is associated with systemic IgG antibody responses in non-allergic individuals. Sigal Leviatan,et al. Immunity.55(12):2454-2469,2022 |
| 2023.1.26 | Reona Tanimura | IL-17-producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice. Vera Kim,et al. JCI Insight. 7(11):e157332,2022 |
| 2023.1.19 | Hiromitsu Asashima | Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis. Ian D Odell,et al. Sci Immunol. 7(78):eabq6691,2022 |
| 2023.1.12 | Taihei Nishiyama | Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses. Huimin Zhang,et al. Nat Immunol. 24(1):96-109,2023 |